Curriculum Vitae

Enrico Brunetta, MD, PhD

Attività clinico-assistenziale e di ricerca

Il Dr. Brunetta lavora attualmente come medico Aiuto nel Dipartimento di Medicina Interna dell’Istituto Clinico Humanitas  (IRCCS) di Rozzano (MI). Il Dipartimento di Medicina Interna è attualmente articolato su diverse aree di competenza tra cui la Medicina Interna, l’Immunologica Clinica, la Reumatologia e la Nefrologia. La partecipazione all’attività di reparto, ambulatoriale e di Day Hospital di medici specialisti in diverse aree internistiche crea i presupposti per la gestione di malattie sistemiche con severo coinvolgimento multiorgano.

Corso di studi e attività formativa

1995-2001  Laurea in Medicina e Chirurgia, Università degli Studi di Padova, Direttore: Prof. G.P. Semenzato.

2001-2005  Specialità in Allergologia ed Immunologia Clinica, Università degli Studi di Padova, Direttore: Prof. G.P. Semenzato.

2006-2008  Post doctoral visiting fellow, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD (USA), Direttore: A.S. Fauci.

2007-2012  Dottorato in Immunologia Clinica, Università degli Studi di Genova, Direttore: Prof. Indiveri/Prof.ssa Mingari.

2019-Corso di perfezionamento II° livello di Epidemiologia e Statistica – Humanitas University

2017-Presente Adjunct Professor, Humanitas University.

Attività accademica

Società scientifiche

Membero Ordinario della Società Italiana di Immunologia Clinica ed Allergologia (SIICA) dal 2005.

Pubblicazioni su riviste internazionali

1: Folci M, Ramponi G, Arcari I, Zumbo A, Brunetta E. Eosinophils as Major Player in Type 2 Inflammation: Autoimmunity and Beyond. Adv Exp Med Biol. 2021 May 26. doi: 10.1007/5584_2021_640. Epub ahead of print. PMID: 34031864.

2: Furlan R, Gatti M, Menè R, Shiffer D, Marchiori C, Giaj Levra A, Saturnino V, Brunetta E, Dipaola F. A Natural Language Processing-Based Virtual Patient Simulator and Intelligent Tutoring System for the Clinical Diagnostic Process: Simulator Development and Case Study. JMIR Med Inform. 2021 Apr 9;9(4):e24073. doi: 10.2196/24073. PMID: 33720840; PMCID: PMC8041050.

3: Lescure FX, Honda H, Fowler RA, Lazar JS, Shi G, Wung P, Patel N, Hagino O; Sarilumab COVID-19 Global Study Group. Sarilumab in patients admitted to hospital with severe or critical COVID-19: a randomised, double-blind, placebo- controlled, phase 3 trial. Lancet Respir Med. 2021 May;9(5):522-532. doi: 10.1016/S2213-2600(21)00099-0. Epub 2021 Mar 4. PMID: 33676590; PMCID: PMC8078879.

4: Pizzocaro A, Colombo P, Vena W, Ariano S, Magnoni P, Reggiani F, Favacchio G, Mirani M, Lavezzi E, Voza A, Calatroni M, Mazziotti G, Lania A; Humanitas COVID-19 Task force. Outcome of Sars-COV-2-related thyrotoxicosis in survivors of Covid-19: a prospective study. Endocrine. 2021 May 28:1–6. doi: 10.1007/s12020-021-02758-2. Epub ahead of print. PMID: 34047879; PMCID: PMC8161706.

5: Peppas S, Pansieri C, Piovani D, Danese S, Peyrin-Biroulet L, Tsantes AG, Brunetta E, Tsantes AE, Bonovas S. The Brain-Gut Axis: Psychological Functioning and Inflammatory Bowel Diseases. J Clin Med. 2021 Jan 20;10(3):377. doi: 10.3390/jcm10030377. PMID: 33498197; PMCID: PMC7863941.

6: Ramponi G, Folci M, De Santis M, Damoiseaux JGMC, Selmi C, Brunetta E. The biology, pathogenetic role, clinical implications, and open issues of serum anti-neutrophil cytoplasmic antibodies. Autoimmun Rev. 2021 Mar;20(3):102759. doi: 10.1016/j.autrev.2021.102759. Epub 2021 Jan 18. PMID: 33476813.

7: Folci M, Ramponi G, Brunetta E. A Comprehensive Approach to Urticaria: From Clinical Presentation to Modern Biological Treatments Through Pathogenesis. Adv Exp Med Biol. 2021 Jan 1. doi: 10.1007/5584_2020_612. Epub ahead of print. PMID: 33385176.

8: Brunetta E, Folci M, Bottazzi B, De Santis M, Gritti G, Protti A, Mapelli SN, Bonovas S, Piovani D, Leone R, My I, Zanon V, Spata G, Bacci M, Supino D, Carnevale S, Sironi M, Davoudian S, Peano C, Landi F, Di Marco F, Raimondi F, Gianatti A, Angelini C, Rambaldi A, Garlanda C, Ciccarelli M, Cecconi M, Mantovani A. Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19. Nat Immunol. 2021 Jan;22(1):19-24. doi: 10.1038/s41590-020-00832-x. Epub 2020 Nov 18. PMID: 33208929.

9: Ramponi G, Folci M, Badalamenti S, Angelini C, Brunetta E. Biomarkers and Diagnostic Testing for Renal Disease in Sjogren’s Syndrome. Front Immunol. 2020 Sep 17;11:562101. doi: 10.3389/fimmu.2020.562101. PMID: 33042142; PMCID: PMC7527442.

10: Canziani LM, Trovati S, Brunetta E, Testa A, De Santis M, Bombardieri E, Guidelli G, Albano G, Folci M, Squadroni M, Beretta GD, Ciccarelli M, Castoldi M, Lleo A, Aghemo A, Vernile L, Malesci A, Omodei P, Angelini C, Badalamenti S, Cecconi M, Cremonesi A, Selmi C; Humanitas and Gavazzeni / Castelli COVID-19 Task Forces. Interleukin-6 receptor blocking with intravenous tocilizumab in COVID-19 severe acute respiratory distress syndrome: A retrospective case- control survival analysis of 128 patients. J Autoimmun. 2020 Nov;114:102511. doi: 10.1016/j.jaut.2020.102511. Epub 2020 Jul 8. PMID: 32713677; PMCID: PMC7342030.

11: Severe Covid-19 GWAS Group, Ellinghaus D, Degenhardt F, Bujanda L, Buti M, Albillos A, Invernizzi P, Fernández J, Prati D, Baselli G, Asselta R, Grimsrud MM, Milani C, Aziz F, Kässens J, May S, Wendorff M, Wienbrandt L, Uellendahl- Werth F, Zheng T, Yi X, de Pablo R, Chercoles AG, Palom A, Garcia-Fernandez AE, Rodriguez-Frias F, Zanella A, Bandera A, Protti A, Aghemo A, Lleo A, Biondi A, Caballero-Garralda A, Gori A, Tanck A, Carreras Nolla A, Latiano A, Fracanzani AL, Peschuck A, Julià A, Pesenti A, Voza A, Jiménez D, Mateos B, Nafria Jimenez B, Quereda C, Paccapelo C, Gassner C, Angelini C, Cea C, Solier A, Pestaña D, Muñiz-Diaz E, Sandoval E, Paraboschi EM, Navas E, García Sánchez F, Ceriotti F, Martinelli-Boneschi F, Peyvandi F, Blasi F, Téllez L, Blanco-Grau A, Hemmrich- Stanisak G, Grasselli G, Costantino G, Cardamone G, Foti G, Aneli S, Kurihara H, ElAbd H, My I, Galván-Femenia I, Martín J, Erdmann J, Ferrusquía-Acosta J, Garcia-Etxebarria K, Izquierdo-Sanchez L, Bettini LR, Sumoy L, Terranova L, Moreira L, Santoro L, Scudeller L, Mesonero F, Roade L, Rühlemann MC, Schaefer M, Carrabba M, Riveiro-Barciela M, Figuera Basso ME, Valsecchi MG, Hernandez- Tejero M, Acosta-Herrera M, D’Angiò M, Baldini M, Cazzaniga M, Schulzky M, Cecconi M, Wittig M, Ciccarelli M, Rodríguez-Gandía M, Bocciolone M, Miozzo M, Montano N, Braun N, Sacchi N, Martínez N, Özer O, Palmieri O, Faverio P, Preatoni P, Bonfanti P, Omodei P, Tentorio P, Castro P, Rodrigues PM, Blandino Ortiz A, de Cid R, Ferrer R, Gualtierotti R, Nieto R, Goerg S, Badalamenti S, Marsal S, Matullo G, Pelusi S, Juzenas S, Aliberti S, Monzani V, Moreno V, Wesse T, Lenz TL, Pumarola T, Rimoldi V, Bosari S, Albrecht W, Peter W, Romero-Gómez M, D’Amato M, Duga S, Banales JM, Hov JR, Folseraas T, Valenti L, Franke A, Karlsen TH. Genomewide Association Study of Severe Covid-19 with Respiratory Failure. N Engl J Med. 2020 Oct 15;383(16):1522-1534. doi: 10.1056/NEJMoa2020283. Epub 2020 Jun 17. PMID: 32558485; PMCID: PMC7315890.

12: Cecconi M, Piovani D, Brunetta E, Aghemo A, Greco M, Ciccarelli M, Angelini C, Voza A, Omodei P, Vespa E, Pugliese N, Parigi TL, Folci M, Danese S, Bonovas S. Early Predictors of Clinical Deterioration in a Cohort of 239 Patients Hospitalized for Covid-19 Infection in Lombardy, Italy. J Clin Med. 2020 May 20;9(5):1548. doi: 10.3390/jcm9051548. PMID: 32443899; PMCID: PMC7290833.

13: Aghemo A, Piovani D, Parigi TL, Brunetta E, Pugliese N, Vespa E, Omodei PD, Preatoni P, Lleo A, Repici A, Voza A, Cecconi M, Malesci A, Bonovas S, Danese S; Humanitas COVID-19 Task Force. COVID-19 Digestive System Involvement and Clinical Outcomes in a Large Academic Hospital in Milan, Italy. Clin Gastroenterol Hepatol. 2020 Sep;18(10):2366-2368.e3. doi: 10.1016/j.cgh.2020.05.011. Epub 2020 May 11. PMID: 32437870; PMCID: PMC7211605.

14: Gatto M, Saccon F, Zen M, Regola F, Fredi M, Andreoli L, Tincani A, Urban ML, Emmi G, Ceccarelli F, Conti F, Bortoluzzi A, Govoni M, Tani C, Mosca M, Ubiali T, Gerosa M, Bozzolo E, Canti V, Cardinaletti P, Gabrielli A, Tanti G, Gremese E, De Marchi G, De Vita S, Fasano S, Ciccia F, Pazzola G, Salvarani C, Negrini S, Puppo F, Di Matteo A, De Angelis R, Orsolini G, Rossini M, Faggioli P, Laria A, Piga M, Mathieu A, Scarpato S, Rossi FW, de Paulis A, Brunetta E, Ceribelli A, Selmi C, Prete M, Racanelli V, Vacca A, Bartoloni E, Gerli R, Larosa M, Iaccarino L, Doria A. Early Disease and Low Baseline Damage as Predictors of Response to Belimumab in Patients With Systemic Lupus Erythematosus in a Real-Life Setting. Arthritis Rheumatol. 2020 Aug;72(8):1314-1324. doi: 10.1002/art.41253. Epub 2020 Jun 12. PMID: 32275125.

15: Dipaola F, Gatti M, Pacetti V, Bottaccioli AG, Shiffer D, Minonzio M, Menè R, Giaj Levra A, Solbiati M, Costantino G, Anastasio M, Sini E, Barbic F, Brunetta E, Furlan R. Artificial Intelligence Algorithms and Natural Language Processing for the Recognition of Syncope Patients on Emergency Department Medical Records. J Clin Med. 2019 Oct 14;8(10):1677. doi: 10.3390/jcm8101677. PMID: 31614982; PMCID: PMC6832155.

16: Brunetta E, Shiffer D, Mandelli P, Achenza S, Folci M, Zumbo A, Minonzio M, Cairo B, Jacob G, Boccassini L, Puttini PS, Porta A, Furlan R. Autonomic Abnormalities in Patients With Primary Sjogren’s Syndrome – Preliminary Results. Front Physiol. 2019 Aug 27;10:1104. doi: 10.3389/fphys.2019.01104. PMID: 31551801; PMCID: PMC6736624.

17: Folci M, Ramponi G, Shiffer D, Zumbo A, Agosti M, Brunetta E. ANCA- Associated Vasculitides and Hematologic Malignancies: Lessons from the Past and Future Perspectives. J Immunol Res. 2019 May 6;2019:1732175. doi: 10.1155/2019/1732175. PMID: 31198793; PMCID: PMC6526571.

18: Dalla Vecchia LA, Barbic F, De Maria B, Cozzolino D, Gatti R, Dipaola F, Brunetta E, Zamuner AR, Porta A, Furlan R. Can strenuous exercise harm the heart? Insights from a study of cardiovascular neural regulation in amateur triathletes. PLoS One. 2019 May 7;14(5):e0216567. doi: 10.1371/journal.pone.0216567. PMID: 31063482; PMCID: PMC6504093.

19: Folci M, Heffler E, Canonica GW, Furlan R, Brunetta E. Cutting Edge: Biomarkers for Chronic Spontaneous Urticaria. J Immunol Res. 2018 Nov 21;2018:5615109. doi: 10.1155/2018/5615109. PMID: 30584542; PMCID: PMC6280255.

20: Brunetta E, Shiffer D, Folci M, Achenza MIS, Puggioni F, Heffler E, Furlan R, Canonica GW. Omalizumab for Idiopathic Nonhistaminergic Angioedema: Evidence for Efficacy in 2 Patients. Case Reports Immunol. 2018 Jul 22;2018:8067610. doi: 10.1155/2018/8067610. PMID: 30140474; PMCID: PMC6081528.

21: Barbic F, Dipaola F, Andreetta F, Brunetta E, Dalla Vecchia L, Mantegazza R, Furlan R, Antozzi C. Long-term cardiovascular autonomic and clinical changes after immunoglobulin G immunoadsorption therapy in autoimmune autonomic ganglionopathy. J Hypertens. 2017 Jul;35(7):1513-1520. doi: 10.1097/HJH.0000000000001355. PMID: 28319594.

22: Cantarini L, Vitale A, Bersani G, Nieves LM, Cattalini M, Lopalco G, Caso F, Costa L, Iannone F, Lapadula G, Galeazzi M, Ceribelli A, Brunetta E, Selmi C, Rigante D. PFAPA syndrome and Behçet’s disease: a comparison of two medical entities based on the clinical interviews performed by three different specialists. Clin Rheumatol. 2016 Feb;35(2):501-5. doi: 10.1007/s10067-015-2890-5. Epub 2015 Feb 10. PMID: 25665824.

23: Dipaola F, Costantino G, Solbiati M, Barbic F, Capitanio C, Tobaldini E, Brunetta E, Zamunér AR, Furlan R. Syncope risk stratification in the ED. Auton Neurosci. 2014 Sep;184:17-23. doi: 10.1016/j.autneu.2014.04.002. Epub 2014 Apr 16. PMID: 24811585.

24: Achenza MI, Meda F, Brunetta E, Selmi C. Serum autoantibodies for the diagnosis and management of autoimmune liver diseases. Expert Rev Gastroenterol Hepatol. 2012 Dec;6(6):717-29. doi: 10.1586/egh.12.58. PMID: 23237257.

25: Varchetta S, Brunetta E, Roberto A, Mikulak J, Hudspeth KL, Mondelli MU, Mavilio D. Engagement of Siglec-7 receptor induces a pro-inflammatory response selectively in monocytes. PLoS One. 2012;7(9):e45821. doi: 10.1371/journal.pone.0045821. Epub 2012 Sep 28. PMID: 23029261; PMCID: PMC3461047.

26: Selmi C, Brunetta E, Raimondo MG, Meroni PL. The X chromosome and the sex ratio of autoimmunity. Autoimmun Rev. 2012 May;11(6-7):A531-7. doi: 10.1016/j.autrev.2011.11.024. Epub 2011 Dec 3. PMID: 22155196.

27: Brunetta E, Hudspeth KL, Mavilio D. Pathologic natural killer cell subset redistribution in HIV-1 infection: new insights in pathophysiology and clinical outcomes. J Leukoc Biol. 2010 Dec;88(6):1119-30. doi: 10.1189/jlb.0410225. Epub 2010 Jul 22. PMID: 20651298.

28: Gurrieri C, Piazza F, Gnoato M, Montini B, Biasutto L, Gattazzo C, Brunetta E, Cabrelle A, Cinetto F, Niero R, Facco M, Garbisa S, Calabrese F, Semenzato G, Agostini C. 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763), a glycogen synthase kinase-3 inhibitor, displays therapeutic properties in a mouse model of pulmonary inflammation and fibrosis. J Pharmacol Exp Ther. 2010 Mar;332(3):785-94. doi: 10.1124/jpet.109.153049. Epub 2009 Dec 3. PMID: 19959748.

29: Brunetta E, Fogli M, Varchetta S, Bozzo L, Hudspeth KL, Marcenaro E, Moretta A, Mavilio D. Chronic HIV-1 viremia reverses NKG2A/NKG2C ratio on natural killer cells in patients with human cytomegalovirus co-infection. AIDS. 2010 Jan 2;24(1):27-34. doi: 10.1097/QAD.0b013e3283328d1f. PMID: 19910789.

30: Ward J, Davis Z, DeHart J, Zimmerman E, Bosque A, Brunetta E, Mavilio D, Planelles V, Barker E. HIV-1 Vpr triggers natural killer cell-mediated lysis of infected cells through activation of the ATR-mediated DNA damage response. PLoS Pathog. 2009 Oct;5(10):e1000613. doi: 10.1371/journal.ppat.1000613. Epub 2009 Oct 2. PMID: 19798433; PMCID: PMC2747015.

31: Brunetta E, Fogli M, Varchetta S, Bozzo L, Hudspeth KL, Marcenaro E, Moretta A, Mavilio D. The decreased expression of Siglec-7 represents an early marker of dysfunctional natural killer-cell subsets associated with high levels of HIV-1 viremia. Blood. 2009 Oct 29;114(18):3822-30. doi: 10.1182/blood-2009-06-226332. Epub 2009 Aug 26. PMID: 19710502; PMCID: PMC2773483.

32: Fogli M, Mavilio D, Brunetta E, Varchetta S, Ata K, Roby G, Kovacs C, Follmann D, Pende D, Ward J, Barker E, Marcenaro E, Moretta A, Fauci AS. Lysis of endogenously infected CD4+ T cell blasts by rIL-2 activated autologous natural killer cells from HIV-infected viremic individuals. PLoS Pathog. 2008 Jul 11;4(7):e1000101. doi: 10.1371/journal.ppat.1000101. PMID: 18617991; PMCID: PMC2438610.

33: Cabrelle A, Dell’Aica I, Melchiori L, Carraro S, Brunetta E, Niero R, Scquizzato E, D’Intino G, Calzà L, Garbisa S, Agostini C. Hyperforin down- regulates effector function of activated T lymphocytes and shows efficacy against Th1-triggered CNS inflammatory-demyelinating disease. J Leukoc Biol. 2008 Jan;83(1):212-9. doi: 10.1189/jlb.0707469. Epub 2007 Oct 18. PMID: 17947392.

34: Dell’Aica I, Niero R, Piazza F, Cabrelle A, Sartor L, Colalto C, Brunetta E, Lorusso G, Benelli R, Albini A, Calabrese F, Agostini C, Garbisa S. Hyperforin blocks neutrophil activation of matrix metalloproteinase-9, motility and recruitment, and restrains inflammation-triggered angiogenesis and lung fibrosis. J Pharmacol Exp Ther. 2007 May;321(2):492-500. doi: 10.1124/jpet.106.116459. Epub 2007 Feb 8. PMID: 17289834.

35: Campo I, Morbini P, Zorzetto M, Tinelli C, Brunetta E, Villa C, Bombieri C, Cuccia M, Agostini C, Bozzi V, Facoetti A, Ferrarotti I, Mazzola P, Scabini R, Semenzato G, Pignatti PF, Pozzi E, Luisetti M. Expression of receptor for advanced glycation end products in sarcoid granulomas. Am J Respir Crit Care Med. 2007 Mar 1;175(5):498-506. doi: 10.1164/rccm.200601-136OC. Epub 2006 Dec 14. PMID: 17170388.

36: Gurrieri C, Bortoli M, Brunetta E, Piazza F, Agostini C. Cytokines, chemokines and other biomolecular markers in sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 2005 Dec;22 Suppl 1:S9-14. PMID: 16457012.

37: Dell’Aica I, Sartor L, Galletti P, Giacomini D, Quintavalla A, Calabrese F, Giacometti C, Brunetta E, Piazza F, Agostini C, Garbisa S. Inhibition of leukocyte elastase, polymorphonuclear chemoinvasion, and inflammation-triggered pulmonary fibrosis by a 4-alkyliden-beta-lactam with a galloyl moiety. J Pharmacol Exp Ther. 2006 Feb;316(2):539-46. doi: 10.1124/jpet.105.096248. Epub 2005 Oct 25. PMID: 16249367.

Specialista in Allergologia ed Immunologia Clinica

Email : enrico.brunetta@humanitas.it